Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations
نویسندگان
چکیده
منابع مشابه
Design and Optimization of Plug Flow Crystallizers
This study presents the development of a plug flow crystallization (PFC) platform consisting of a vortex mixer combined with a tubular reactor. Process analytical technologies (FBRM, PVM, FT-IR) were applied in-situ in order to characterize and optimize crystallizations via the use of novel flow cells. In addition to this a new calibration free method for concentration monitoring was successful...
متن کاملContinuous Crystallization of Proteins in a Tubular Plug-Flow Crystallizer
Protein crystals have many important applications in many fields, including pharmaceutics. Being more stable than other formulations, and having a high degree of purity and bioavailability, they are especially promising in the area of drug delivery. In this contribution, the development of a continuously operated tubular crystallizer for the production of protein crystals has been described. Us...
متن کاملMathematical Modeling and Design of Novel Semi-continuous and Continuous Crystallizations
Crystallization is an important separation technology used for the purification of products during their final stages of manufacturing. Novel semi-continuous and continuous crystallization process designs are receiving increasing attention in pharmaceutical industry due to significant advantages in terms of process, operation and costs. This dissertation aims to develop mathematical models for ...
متن کاملinvestigating the feasibility of a proposed model for geometric design of deployable arch structures
deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
MATHEMATICAL MODELING AND PERFORMANCE OPTIMIZATION FOR THE DIGESTING SYSTEM OF A PAPER PLANT
This paper deals with the mathematical modeling and performance optimization for the Digesting system of a Paper Plant using Genetic Algorithm. The Digesting system of a Paper Plant has four main subsystems, arranged in series and parallel. Considering exponential distribution for the probable failures and repairs, the mathematical formulation of the problem is done using probabilistic approach...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2015
ISSN: 1083-6160,1520-586X
DOI: 10.1021/acs.oprd.5b00110